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Synthesis of 5-substituted 4-O-methyl tetramates

✍ Scribed by Raymond C.F Jones; Andrew D Bates

No coin nor oath required. For personal study only.

✦ Synopsis

4-Methoxy-A3 -pyrrolin-2-ones (4-O-methyl tetramates) are _ alkylated at C-5 via a lithio-derivative;

an N-substituent may be introduced either during or after heterocycle formation.

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## Abstract For Abstract see ChemInform Abstract in Full Text.

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