Synthesis of 5-N-glycosylaminopyrimidines. A new class of compounds with potential anti-aids activity

✍ Scribed by M. D. López; M. L. Quijano; A. Sánchez; M. Nogueras

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2000
• Tongue: English
• Weight: 784 KB
• Volume: 37
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570370617

✦ Synopsis

Abstract

Reactions between 5,6‐diaminopyrimidines 1a‐c and pentoses 2a‐e yield 5‐N‐glycosylaminopyrirnidines or 7‐polyhydroxyalkylpteridines, depending on the presence or absence of acetic acid. The “in vitro” anti‐HIV activity of 6‐amino‐2‐methoxy‐3‐methyl‐5‐N‐D‐ribosylaminopyrimidin‐4(3__H__)‐one 3e, 6‐amino‐2‐methoxy‐3‐methyl‐5‐N‐β‐D‐xylopyranosylaminopyrimidin‐4(3__H__‐one 3f, and 6‐amino‐2‐methylthio‐5‐N‐β‐L‐xylopyranosylminopyrimidin‐4(3__H__)‐one 3k, appears to be promising.