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Synthesis of 5-Methylaminomethyl-2-thiouridine, a Rare Nucleoside from t-RNA

✍ Scribed by Dr. Helmut Vorbrüggen; Konrad Krolikiewicz

Publisher
John Wiley and Sons
Year
1975
Tongue
English
Weight
227 KB
Volume
14
Category
Article
ISSN
0044-8249

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📜 SIMILAR VOLUMES

Nucleoside Syntheses, XXI. Synthesis of
Nucleoside Syntheses, XXI. Synthesis of 5-Methylaminomethyl-2-thiouridine, a Rare Nucleoside from t-RNA
✍ Vorbrüggen, Helmut ;Krolikiewicz, Konrad 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 English ⚖ 584 KB

## Abstract The synthesis of 5‐methylaminomethyl‐2‐thiouridine **(1)**, a rare nucleoside from t‐RNA, starting from the appropriate 2‐thiouracil and ribose derivatives is described. During the silyl Hilbert‐Johnson nucleoside synthesis with silver perchlorate the __tert__‐butoxycarbonyl (Boc) amino

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Increasing research has focused on examining the similarity between pyridopyrimidines and pyrimido [2,3-d]pyrazines, also referred to as pteridines [1]. Significant antitumor activity against Walker muscular carcinosarcoma in rats has been demonstrated for 4-oxopyrido [2,3-d]pyrimidine (A) and 2,4-d