Synthesis of 5-ethynylcytosine and 5-ethynylcytidine
✍ Scribed by A.S. Jones; P. Serafinowski; R.T. Walker
- Book ID
- 104236049
- Publisher
- Elsevier Science
- Year
- 1977
- Tongue
- French
- Weight
- 134 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract A variety of 5‐aryl‐(20__S__)‐camptothecin derivatives were synthesized by the reaction of 5‐hydroxy‐(20__S__)‐camptothecin with aromatic hydrocarbons under Friedel‐Craft reaction conditions in moderate to good yield as diastereomeric pairs. The methodology was then extended for the syn
## Abstract (__S__)‐5,5,5,5′,5′,5′‐Hexafluoroleucine ((__S__)‐13) of 81 % ee is prepared from hexafluoroacetone (l) and ethyl bromopyruvate (= ethyl 2‐oxopropanoate) in 7 steps with an overall yield of 18% (__Schemes 1__ and __2__). Key step in this sequence is the highly enantioselective reduction