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Synthesis of 5-cyanopyrazolo[3,4-b]pyridines in the reaction of 5-amino-3-methyl-1-phenylpyrazole with arylidene derivatives of malonodinitrile and ethyl cyanoacetate

✍ Scribed by Jairo Quiroga; Mario Alvarado; Braulio Insuasty; Rodolfo Moreno; Enrique Raviña; Isabel Estevez; Regina H. De Almeida S.

Publisher
Journal of Heterocyclic Chemistry
Year
1999
Tongue
English
Weight
328 KB
Volume
36
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

This paper describes the synthesis of a new series of 6‐amino‐4‐aryl‐5‐cyanopyrazolo[3,4‐b]pyridines 4 and 4‐aryl‐5‐cyano‐6__H__‐pyrazolo[3,4‐b]pyridin‐6‐ones 5 from the reaction of 5‐amino‐3‐methyl‐1‐phenylpyrazole 1 with arylidene derivatives of malonodinitrile 2 and ethyl cyanoacetate 3. The structure of the final compounds was determined on the basis of nmr measurements, especially by ^1^H, ^1^H‐, ^1^H, ^13^C‐COSY, DEPT and X‐ray diffraction.

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