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Synthesis of 5-(4-substituted benzyl)-2,4-diaminoquinazolines as inhibitors of candida albicans dihydrofolate reductase

✍ Scribed by G. Erik Jagdmann Jr.; Joseph H. Chan; Virgil L. Styles; Robert L. Tansik; Christine M. Boytos; Sharon K. Rudolph

Book ID: 112131351
Publisher: Journal of Heterocyclic Chemistry
Year: 1995
Tongue: English
Weight: 391 KB
Volume: 32
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570320508

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## Abstract Nonclassical 2,4‐diamino‐5‐substituted furo[2,3‐__d__]pyrimidines **4a‐i, 5a‐b** and **7a‐f** were synthesized as extended aromatic ring appended analogs of previously reported antifolates **1a‐b.** The extended aromatic system was designed to better interact with a phenylalanine residu