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Synthesis of 5-(1-azido-2-haloethyl)arabinouridines

✍ Scribed by Rakesh Kumar; Leonard I. Wiebe; Edward E. Knaus

Publisher: Journal of Heterocyclic Chemistry
Year: 1997
Tongue: English
Weight: 152 KB
Volume: 34
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570340445

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✦ Synopsis

Abstract

A novel class of 5‐(1‐azido‐2‐haloethyl)arabinouridines 4–6 was synthesized by the regiospecific addition of halogenoazides (XN~3~: X = C1, Br, I) to the vinyl substituent of 5‐vinylarabinouridine (7). The title 5‐(1‐azido‐2‐haloethyl)arabinouridines 4–6 were previously shown to exhibit significant in vitro antiviral activity against herpes simplex virus type 1, varicella zoster virus and cytomegalo virus.

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