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Synthesis of 4H-1,4-oxazines as transthyretin amyloid fibril inhibitors

โœ Scribed by Li, Weipeng; Duan, Xiaowei; Yan, Hong; Xin, Hongxing


Book ID
120335940
Publisher
Royal Society of Chemistry
Year
2013
Tongue
English
Weight
384 KB
Volume
11
Category
Article
ISSN
1477-0520

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โœ Xiao Tian; Li-Ying Wang; Shuai Xia; Zhu-Bo Li; Xing-Hui Liu; Yuan Yuan; Liang Fa ๐Ÿ“‚ Article ๐Ÿ“… 2012 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 534 KB

Novel 2H-benzo[b][1,4]oxazin-3(4H)-ones have been synthesized by condensation, reduction, O-alkylation and Smiles rearrangement using 3-bromo-4-hydroxy benzaldehyde, anilines, and chloroacetyl chloride as starting materials. All the synthesized compounds have been characterized by (1)H NMR, (13)C NM