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Synthesis of 4-Trifluoromethylpyrimido[4,5-c]pyridazine-5,7-diones from Uracils.

โœ Scribed by Masahiko Takahashi; Yoshinobu Ogawa; Kazuhiro Inoue


Book ID
102000561
Publisher
John Wiley and Sons
Year
2007
Weight
31 KB
Volume
38
Category
Article
ISSN
0931-7597

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A novel synthesis of 3-(substituted)pyri
โœ Anjanette J. Turbiak; Jeff W. Kampf; H.D. Hollis Showalter ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 271 KB

An improved synthesis of 3-(substituted)pyrimido[4,5-c]pyridazine-5,7(1H,6H)-diones, a known subclass of 4-deazatoxoflavins, is reported. The approach involves treatment of 3-methyl-6-(1-methylhydrazinyl)uracil with representative phenyl and alkyl glyoxal monohydrates, which in turn are obtained by