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Synthesis of 4-substituted aminobenzoate quaternary salts as potent antispasmodic agents

โœ Scribed by Elsebai A. Ibrahim; Raafat Soliman; Mohamed Gabr


Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
351 KB
Volume
68
Category
Article
ISSN
0022-3549

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โœฆ Synopsis


N-(Diethylaminoethyl)-4-substituted aminobenzoate quaternary salts, N-(diethylaminoethyl)-4-substituted aminobenzamide quaternary salts, 4-substituted acylaminobenzamide quaternary salts, and 4-substituted acylaminosalicylamide derivatives were prepared and tested for antispasmodic activity. Preliminary pharmacological tests on isolated guinea pig ileum revealed that the new compounds possess nonspecific inhibitory action on smooth muscles.


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Synthesis of Some Novel Substituted Quinolines as Potent Analgesic Agents. -The title products, e.g. (II), (IV), and (VI) are prepared in order to study their analgesic activity. The isoxazolo quinolines (II) are the most potent derivatives among the prepared compounds exhibiting an activity simila