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Synthesis of 4-substituted 4-arylpiperidines

✍ Scribed by Geraldine C.B Harriman; Jianxing Shao; Jay R Luly

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
59 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

Several novel 4-substituted 4-arylpiperidines were synthesized. The chemistry leading to 4-(4chlorophenyl)-4-fluoropiperidine (6), 4-azido-4-(4-chlorophenyl)piperidine ( 7) and 4-(4-chlorophenyl)-4methylpiperidine (8) is described.

📜 SIMILAR VOLUMES

Conformational analysis of 1-arylpiperaz
Conformational analysis of 1-arylpiperazines and 4-arylpiperidines
✍ Gerard D. H. Dijkstra 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 741 KB

## Abstract A conformational analysis of 1‐arylpiperazines and 4‐arylpiperidines is presented using molecular‐mechanics and semi‐empirical calculations. It has been found that electronic effects of substituents on the aryl ring determine the conformational behaviour of 1‐arylpiperazines. Steric eff