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Synthesis of 4-mono- and dialkyl-2′-deoxycytidines and their insertion into an oligonucleotide

✍ Scribed by A. Kraszewski; A.M. Delort; R. Teoule

Book ID
104218235
Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
200 KB
Volume
27
Category
Article
ISSN
0040-4039

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✦ Synopsis

Starting with 4-thio-2'-deoxyuridine, the simple synthesis of N4-mono-and dialkyl-2'-deoxycytidines is described. The N4-methyl derivative has been incorporated into the oligonucleotide chain d(CGm4CGCG).

Among so-called unusual nucleosides found in RNAs and DNAs, N4-alkylated nucleosides

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✍ Anthony Romieu; Didier Gasparutto; Didier Molko; Jean Cadet 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 437 KB

A O l c 5-h b s u p h c p i m n s o w c e m s c a e d c w W d 0 1 E S L 5-Hydroxy-2'-deoxycytidirte (5-OHdC) 2 is one of the major stable "OH radicals and one-electron mediated oxidation products of 2'-deoxycytidine 1. Diflkrent studies have ahovm that the level of 2 increases substantially when DN