Synthesis of 4-hydroxy-2-methylisocarbostyril-3-carboxanilides
✍ Scribed by Joseph G. Lombardino
- Book ID
- 112122263
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1970
- Tongue
- English
- Weight
- 330 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0022-152X
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## Abstract 3‐Acetyl‐4‐hydroxy‐chromen‐2‐one (**1**) was brominated with phenyltrimethylammonium tribromide to afford 3‐(2‐bromoacetyl)‐4‐hydroxy‐chromen‐2‐one (**2**) whose reactions with thiourea, thioacetamide and ammonium dithiocarbamate gave respectively 3‐(2‐amino‐thiazol‐4‐yl)‐4‐hydroxy‐, 4‐
A short chemical process is described for the synthesis of optically active 3y roxy-4-alkoxycarbonyl-Z-azetidinones (R-lactams) from L-tartaric acid. Tartaric acid is an extremely useful and versatile member of the chiral pool. Since nearly any type of f+hydroxy acid can be converted to a 8-lactam (