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Synthesis of 4- cis -Phenyl- l -proline via Hydrogenolysis

โœ Scribed by Tamaki, Makoto; Han, Guoxia; Hruby, Victor J.


Book ID
126005380
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
64 KB
Volume
66
Category
Article
ISSN
0022-3263

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Pd(PPh 3 ) 4 /PPh 3 -catalyzed hydrogenolysis of 3a derived from trans-4-hydroxy-L-proline using ammonium formate as a hydride reagent, provides olefin 4 as a major product, which is hydrolyzed to give (+)-a-allokainic acid.