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Synthesis of 4-amino-6-(hetaryl)pyridazin-3-ones as analogs of pyridazine-based cardiotonic agents

✍ Scribed by N. N. Smolyar; Yu. M. Yutilov; S. V. Gres′ko

Book ID: 106491994
Publisher: Springer
Year: 2009
Tongue: English
Weight: 74 KB
Volume: 43
Category: Article
ISSN: 0091-150X
DOI: 10.1007/s11094-009-0249-4

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## Abstract magnified image Novel routes to 3‐aminopyridazines, 10a__H__‐pyridazino[1,6‐__a__]quinazoline and, thieno[3,4‐__d__]pyridazine utilizing the reaction of 2‐oxobutanal‐1‐arylhydrazones **3a,b** with α,β‐unsaturated nitriles are described. Condensation of **3** with ethyl cyanoacetate aff