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Synthesis of 4-amino-5,6,7,8-tetrahydrothieno[2,3-b]quinolin-5-ol derivatives

✍ Scribed by Yang-Heon Song; Jinmoo Seo

Publisher
Journal of Heterocyclic Chemistry
Year
2007
Tongue
English
Weight
296 KB
Volume
44
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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This paper describes the synthesis of 4‐amino‐5,6,7,8‐tetrahydrothieno[2,3‐b]quinolin‐5‐ol derivatives (3a‐h) and 4‐amino‐5,6,7,8‐tetrahydrothieno[2,3‐b]quinoline (8a) in good yield by three‐step procedures starting from 2‐aminothiophene‐3‐carbonitrile and 5‐substituted cyclohexane‐1,3‐dione.

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## Abstract magnified image The synthesis of 9‐amino‐5,6,7,8‐tetrahydrothieno[3,2‐__b__]quinoline (**3**) and 9‐amino‐5,6,7,8‐tetrahydrothieno[3,2‐__b__]quinolin‐5‐ol derivatives (**4a**, **4b**, **4c**, **4d**, **4e**, **4f**, **4g**) in good yield by three‐step procedures starting from 3‐aminothi