✦ LIBER ✦

Synthesis of 4-amino-3-cyano-2- methylsulfanyl-1H-[1,5]benzodiazepine, benzo[1,3]azole, and pyrazolobenzo[1,3]azole derivatives via a new utility of bis(methylsulfanyl)methylene derivatives

✍ Scribed by Eman A. El-Rady; Mohamed A. Khalil; Fawi M. Abd El Latif

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 91 KB
Volume: 15
Category: Article
ISSN: 1042-7163
DOI: 10.1002/hc.20031

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✦ Synopsis

Abstract

Novel polysubstituted 1,5‐benzodiazepine 5, 2,2‐bis(methylthio)benzoxazoles 8a–d, 2,2‐bis‐ (acetyl)benzoxazole 8e, 2‐(3‐methyl‐1‐phenylpyrazolo‐ 4‐yl)benzoazole derivatives 16a–c, as well as the previously reported 2‐di[cyano(acetyl)‐methylene]benzothiazoles 7a,b have been obtained via a new utility of ketene dithioacetals 1a,b and 12 with aniline derivatives 2. Rationales for the reactions pathways are presented. © 2004 Wiley Periodicals, Inc. Heteroatom Chem 15:407–412, 2004; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20031

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