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Synthesis of 3H-Tyr-D-Ala-Gly-N(Me)Phe chloromethyl ketone—an opioid affinity label

✍ Scribed by E. Varga; G. Tóth; J. Hepp; S. Benyhe; J. Simon; K. Medzihradszky; A. Borsodi


Book ID
119073723
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
438 KB
Volume
12
Category
Article
ISSN
0143-4179

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Synthesis of [3H] tyr-D-thr-gly-phe(pN3)
✍ G. Gacel; E. Fellion; B. B. Roques; R. Genet; J. J. Morgat; P. Fromageot 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 French ⚖ 388 KB

## 3 In a previous work, the synthesis of [ HI Tyr-D-Thr-Gly-Phe-Leu-Thr (DTLET), a highly selective probe for 6 opioid receptors has been described. More recently, Az-DTLET (Tyr-D-Thr-Cly-Phe (pN 1-Leu-Thr) has been shown to be a specific and irreversible photoaffinity ligand for 6 opioid sites.