Synthesis of 3,9-dialkylguanines and their conversion into 3-alkylwyes, models for the fluorescent nucleosides from phenylalanine transfer ribonucleic acids

Synthesis of [R-(R∗,S∗)]- and [S-(R∗,R∗)

Synthesis of [R-(R∗,S∗)]- and [S-(R∗,R∗)]β-hydroxy-3-(β-d-ribofuranosyl)-wybutines, the most probable alternatives for the hypermodified nucleoside of rat liver phenylalanine transfer ribonucleic acid

✍ Taisuke Itaya; Tae Kanai; Takehiko Iida 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 213 KB

The synthesis of the title compounds started with the Vilsmeier reaction of 3-[2,3,5-tris-O-(tert-butylalmethylsilyl)-~-D-ribofuranosyl]wye (b'b) and proceeded through the Wittig reaction with (R)-N-(methoxyearbonyl)-3-(triphenylphosphonio)alaninate (4), methylation with trimethyisilyldiazomethane,