Synthesis of 3,5-diisopropyl[carboxy-14C]salicylic acid and its 67CU complex

✍ Scribed by Mankulathu V. Chidambaram; Claude E. Epperson; Skip Williams; Ronda A. Gray; John R. J. Sorenson

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: French
• Weight: 568 KB
• Volume: 29
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580290305

✦ Synopsis

Abstract

The synthesis of 3,5‐diisopropyl[carboxy‐^14^C]salicylic acid was achieved via Kolbe‐Schmitt carboxylation of potassium 2,4‐diisopropylphenolate. The yield of this acid was 81% based upon the weight of the product and 93% based upon radioactivity incorporated into the labeled acid which contains 98% ^14^C in the carboxyl group (specific activity = 5.1 μCi/mg). The labeled acid was characterized by ultraviolet spectrophotometry and purity established by thin‐layer chromatography, autoradiography, and liquid scintillation counting. A 90% yield of the double labeled ^14^C, ^67^Cu‐complex (specific activity = 4.6 μC/mg) was obtained using conditions developed with non‐radioactive reactants. The presence of ^67^Cu in this complex was established using γ‐ray emission spectrophometry.