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Synthesis of 35-Deoxy Amphotericin B Methyl Ester: A Strategy for Molecular Editing

✍ Scribed by Alex M. Szpilman; Damiano M. Cereghetti; Nicholas R. Wurtz; Jeffrey M. Manthorpe; Erick M. Carreira


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
328 KB
Volume
120
Category
Article
ISSN
0044-8249

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## Abstract Enantioselective synthesis of deoxy analogues of pyranonaphthoquinone antibiotics (+)‐nanomycin A methyl ester, (+)‐eleutherin, (+)‐allo‐eleutherin, and (+)‐thysanone was achieved in good overall yield with high enantio‐ and diastereoselectivity from the common intermediate (__R__)‐3‐(2