Synthesis of 3,4-Fused Bicyclic β-Lactams and Their Transformation into Methyl cis-3-Aminotetrahydrofuran-2-carboxylates
✍ Scribed by Erika Leemans; Matthias D'hooghe; Yves Dejaegher; Karl W. Törnroos; Norbert De Kimpe
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 234 KB
- Volume
- 2010
- Category
- Article
- ISSN
- 1434-193X
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The synthesis of a d'carbapenem and two ,?-lactams possessing a Br-atom at the N-substituting center not involved in the lactam ring and bearing the carboxyl group is described. The ,?-lactams having this kind of Br-substitution are more susceptible to nucleophilic attack than those having a conjuga
## Abstract The enantioselective synthesis of (+)‐ and (−)‐__cis__‐2‐methyl‐4‐propyl‐1,3‐oxathine **8** and **9** form (__E__)‐2‐hezen‐1‐ol (**1**) as common starting material is described. The two enantiomeric forms exhibit different organoleptic properties.