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Synthesis of 3,4-dihydroquinazolin-4-one: selenium-catalyzed reductive N-heterocyclization of N-(2-nitrobenzoyl)amides with carbon monoxide

โœ Scribed by Yutaka Nishiyama; Masaharu Hirose; Wataru Kitagaito; Noboru Sonoda

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
84 KB
Volume
43
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A catalytic synthetic method of 3,4-dihydroquinazolin-4-ones has been developed. When N-(2-nitrobenzoyl)amides were treated with carbon monoxide in the presence of a catalytic amount of selenium, reductive N-heterocyclization of N-(2-nitrobenzoyl)amide efficiently proceeded to give the corresponding 3,4-dihydroquinazolin-4-ones in moderate to good yields.

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