Synthesis of 3,4-Dihydroisoquinolines by a C(sp3)H Activation/Electrocyclization Strategy: Total Synthesis of Coralydine

✍ Scribed by Manon Chaumontet; Riccardo Piccardi; Olivier Baudoin

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 321 KB
• Volume: 121
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/ange.200804444

✦ Synopsis

In memory of Christian Marazano

Isoquinolines, in various oxidation states (for example, isoquinolines, dihydro-and tetrahydroisoquinolines), are found in numerous natural products [1] and bioactive molecules, such as the tetrahydroprotoberberine alkaloid coralydine [2] and the peripheral benzodiazepine receptor ligand PK11195 (see below).