Synthesis of 3,4-Dihydroisoquinolin-1-ones from N -Boc-(β-Arylethyl)carbamates via Isocyanate Intermediates
✍ Scribed by In, Jinkyung; Hwang, Soonho; Kim, Changhun; Seo, Jae Hong; Kim, Sanghee
- Book ID
- 118223210
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 580 KB
- Volume
- 2013
- Category
- Article
- ISSN
- 1434-193X
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A convenient, high yield one-pot methodology for the synthesis of pharmaceutically interesting 3-unsubstituted-2,4-oxazolidinediones from a-hydroxyesters is described. A primary carbamate was generated in situ from the corresponding a-hydroxyester and trichloroacetyl isocyanate, then converted to th
## Abstract magnified image The synthesis of a novel series of analogous intermediates __N__^3^‐[1‐alkyl(aryl/heteroaryl)‐3‐oxo‐4,4,4‐trichloroalk‐1‐en‐1‐yl]‐2,3‐diaminopyridines and __N__^2^‐(methanesulfonyl) [Cl~3~CC(O)CHCRNH(C~5~H~3~N)NHY], where R = H, Me, C~6~H~5~, 4‐FC~6~H~4~, 4‐ClC~6~H~4~
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v