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Synthesis of 3,4-Dihydro-2 H -1,3,5-thiadiazines

โœ Scribed by Katritzky, Alan R.; Vakulenko, Anatoliy V.; Xu, Yong-Jiang; Steel, Peter J.


Book ID
121847131
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
53 KB
Volume
67
Category
Article
ISSN
0022-3263

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The reaction of 3-mercapto-4-aryIideneamino-l,2,4triazoles 2b-d, 3a-d with ethyl bromoacetate and/or phenacyl bromide in hot DMF and triethylamine affords the stereochemically pure 7-acyl-6-aryl-6,7dihydro-5H-lt2, 4-triazolo[3,4-b][l, 3,4]thiadiazines