Synthesis of 3-trialkylsilyl pyrazoles from β-oxo acylsilanes

✍ Scribed by Stéphane Gérard; Richard Plantier-Royon*; Jean-Marc Nuzillard; Charles Portella

• Publisher: Elsevier Science
• Year: 2000
• Tongue: French
• Weight: 67 KB
• Volume: 41
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)01724-x

✦ Synopsis

The synthesis of b-oxo acylsilanes via cyclic sulfates is described and applied to carbohydrates. These compounds are used for the synthesis of new silylated pyrazoles linked to a carbohydrate moiety by the addition of hydrazines. The regiochemistry of the reaction was determined by NMR analyses ( 1 H/ 13 C and 1 H/ 15 N correlations).