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Synthesis of 3-pyrrolines via a [4+1]-annulation strategy

โœ Scribed by Albert Padwa; Bryan H. Norman


Book ID
103399910
Publisher
Elsevier Science
Year
1988
Tongue
French
Weight
251 KB
Volume
29
Category
Article
ISSN
0040-4039

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Heating azidcdienes 19 at 70ยฐC produced the tricyclic 3-pyrrolines 20 and 21 in one operation. The diastereoselectivity of this process was examined, and found to be controlled by the conformation of the cyclization precursor. Compound 20d incorporates the basic features of gephyrotoxin 3. Fused bi