Wittig-Horner reagents (1a-e) react with 1,3-dioxo-D 2,␣ -indanmalononitrile (2) to give the phosphonate adducts 3, 4, 5, 6, and 7, respectively. Structural reasoning for the new products was based on compatible analytical and spectral data (IR, 1 H, 31 P NMR, and MS). The mechanism that accounts fo
Synthesis of 3- (1 -alkenyloxy) -1,2-propanediols, enol ethers of glycerol, by the horner-wittig reaction
✍ Scribed by T. A. M. van Schaik; A. van der Gen
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 172 KB
- Volume
- 102
- Category
- Article
- ISSN
- 0165-0513
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A simple and efficient route to monoprotected E-and Z-2-alkylidene-1 ,Zpropanediols was developed. The key step involves an unusual regio-and stereoselective SR2' Mitsunobu reaction of substituted 3-hydtoxy-2methylenealkenoate. We recently reported that 3.4,~tri-0-benzyl-D-glucose could be used as a
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