SYNTHESIS OF 2α,3α-DIHYDROXY-Δ4,7-6-KETOSTEROIDS, STRUCTURAL ANALOGS OF DIAULUSTEROLS A AND B
✍ Scribed by N. V. Kovganko; S. N. Sokolov
- Book ID
- 110329287
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 59 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0009-3130
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Syn thes is of 14C -labe 1 led 4 -chloro -3 -s u l f amoyl -N -(3aa, 4a, 5 , 6 7a,7aa-hexahydro-4,7-methano-isoindolin-Z-yl)-benzamide.
## Abstract Tritiation of 7‐oxo‐5‐cholestene‐3β,26‐diol diacetate afforded a mixture of [5α,6α‐^3^H~2~] products which were reduced with lithium aluminum hydride to provide a mixture of [5α,6α‐^3^H~2~]‐3β, (7α and 7β), 26‐triols an 3β, 26‐diol. Oxidation with Jones reagent provided 3,7‐dioxo and 3‐