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Synthesis of (2S)-4,4-difluoroproline, (2S,4R)-4-fluoroproline and their derivatives from (S)-aspartic acid [1]

✍ Scribed by Klaus Burger; Martin Rudolph; Susanna Fehn; Norbert Sewald


Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
435 KB
Volume
66
Category
Article
ISSN
0022-1139

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## Abstract A new synthetic route to enantiopure (2__S__,4__R__)‐4‐hydroxypipecolic acid from commercial ethyl (3__S__)‐4‐chloro‐3‐hydroxybutanoate is reported. The synthesis is based on the Pd‐catalyzed methoxycarbonylation of a 4‐alkoxy‐substituted δ‐valerolactam‐derived vinyl triflate followed b