✦ LIBER ✦
Synthesis of [2H13]heptanoic acid via the desulfurization of methyl 3-chloro-5,6-dibromothieno[3,2,b]thiophene-2-carboxylate with nickel-aluminium alloy in NaOD-D2O solution
✍ Scribed by Hirohisa Tsuzuki; Mamoru Mukumoto; Takehito Tsukinoki; Shuntaro Mataka; Masashi Tashiro; Tadashi Yonemitsu; Yoshiaki Nagano
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- French
- Weight
- 222 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
[^2^H~13~]Heptanoic acid was synthesized as its methyl ester (4) (deuterium content: 96%) with Ni‐Al alloy in 10% NaOD‐D~2~O via the desulfurization of methyl 3‐chloro‐5,6‐dibromothieno[3,2,b]thiophene‐2‐carboxylate (3), which was derived from 4,5‐dibromothiophene‐2‐carboaldehyde (1) in two steps.