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Synthesis of 2H labelled diasteromeric isoxazolidines by 1,3-dipolar cycloadditions of nitrones to alkenes

✍ Scribed by Angelo Liguori; Paolo Mascaro; Giovanni Sindona; Nicola Uccella


Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
328 KB
Volume
28
Category
Article
ISSN
0022-2135

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✦ Synopsis


Abstract

Specifically labelled ^2^H isoxazolidine epimers have been synthesized from suitably labelled nitrones and styrenes by 1,3‐dipolar cycloaddition.


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## Abstract 1,3‐Dipolar cycloaddition of nitrones with ethyl vinyl ether or 2,3‐dihydrofuran proceeds smoothly in the presence of a catalytic amount (10 mol%) of ytterbium triflate to afford isoxazolidines and dicyclic isoxazolidine respectively with good yields and high stereoselectivity.