Synthesis of (25R)-cholest-5-ene-3β, 26-diol and its radiolabeled analog
✍ Scribed by Thomas E. D'Ambra; Norman B. Javitt; Koji Nakanishi; Tadeusz Warchol
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 198 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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## Abstract The 21‐(3‐hydroxy‐3‐methylbutyl)‐ and 21‐(2‐hydroxy‐2‐methylpropoxy)cholestane derivatives 3 and 5, formally double chain hybrid (20__R__)‐ and (20__S__)‐cholesterol analogues, were synthesized. The C‐22 to C‐27 section of the 25‐hydroxycholestane side chain was established by stereosel
(25R)-5 alpha-Cholest-8(14)-ene-3 beta,15 beta,26-triol (III) was prepared by reduction of (25R)-3 beta,26-diacetoxy-5 alpha-cholest-8(14)-en-15-one with sodium borohydride followed by treatment of the crude product with lithium aluminium hydride. The trihydroxysterol III, a potential metabolite of
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v