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Synthesis of 2,5-bis(2′-piperidylmethyl) piperidine and related compounds

✍ Scribed by Metwally Hammouda; Ez-el-Din Kandeel; Wafaa Hamama; Elsayed Afsah

Book ID
112960068
Publisher
Springer
Year
1993
Tongue
English
Weight
223 KB
Volume
16
Category
Article
ISSN
0253-6269

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Synthesis of N-(2-piperidylmethyl)-2,5-B
Synthesis of N-(2-piperidylmethyl)-2,5-BIS(2,2,2-trifluoroethoxy)benzamide-carbonyl-14C acetate (flecainide-14C acetate)
✍ E. H. Banitt; G. J. Conard 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 281 KB 👁 1 views

## Abstract N‐(2‐Piperidylmethyl)‐2,5‐bis(2,2,2‐trifluoroethoxy)benzamide acetate (flecainide acetate; R‐818), a new antiarrhythmic agent, was labelled with carbon‐14 at the carboxamide position for metabolic studies. A three‐step synthetic route starting from 2,5‐dihydroxybenzoic acid‐carboxyl‐^14