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Synthesis of 2,4,6-trisubstituted naphthalenes via novel copper-promoted tandem coupling and intramolecular cyclization

✍ Scribed by Yuguang Wang; Bingchun Zhu; Qin Zhu

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 119 KB
Volume: 23
Category: Article
ISSN: 0268-2605
DOI: 10.1002/aoc.1531

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✦ Synopsis

Abstract

An unprecedented copper‐promoted tandem coupling and intramolecular cyclization reaction is disclosed. This strategy offers a simple and promising method for accessing 2,4,6‐trisubstituted naphthalenes. A reaction mechanism involving initial formation of diynes followed by a 6‐exo‐dig cyclization and subsequent rearrangement is proposed. Copyright © 2009 John Wiley & Sons, Ltd.

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