Synthesis of |24-14C|-23-norcholanoic acid derivatives
โ Scribed by M. S. Maier; A. M. Seldes; E. G. Gros
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- French
- Weight
- 376 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0022-2135
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๐ SIMILAR VOLUMES
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The syntheses of 24-methylidene[24-14C]cholesterol (7a) and of 24-methylidene[7-3H]cholesterol (7b) from commercially available (20S)-3-oxopregn-4-ene-20-carbaldehyde (1) are described. The method also provides simple preparations of 3P-aceto~y[24-'~C]chol-5-en-24-oic acid (4) and 24-oxocholest-5-en
## Abstract The title work proceeds in five steps and 16% overall yield from sodium [1โ^14^C]acetate, which was converted by bromination followed by ethoxide displacement and reaction with phthaloyl dichloride to ethoxy[1โ^14^C]acetyl chloride. The thermal[2+2]cycloaddition of tetraethoxyethene wit