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Synthesis of 2,3,4-Trisubstituted Thiochromanes using an Organocatalytic Enantioselective Tandem Michael–Henry Reaction

✍ Scribed by Rajasekhar Dodda; Joshua J. Goldman; Tanmay Mandal; Cong-Gui Zhao; Grant A. Broker; Edward R. T. Tiekink


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
176 KB
Volume
350
Category
Article
ISSN
1615-4150

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## Abstract An enantioselective oxa‐Michael–Henry reaction of substituted salicylaldehydes with nitroolefins that proceeds though an aromatic iminium activation (AIA) has been developed by using a chiral secondary amine organocatalyst and salicylic acid as a co‐catalyst. The corresponding 3‐nitro‐2