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Synthesis of 2,3-Disubstituted Pyrroles from 3, N -Dilithio- N -( tert -butyldimethylsilyl)-2-buten-1-amine

โœ Scribed by Jacobson, Madeleine A.; Williard, Paul G.

Book ID
126133644
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
103 KB
Volume
67
Category
Article
ISSN
0022-3263

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โœ Yanbing Liu; Gordon W Gribble ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 63 KB

Generation of 2,3-dilithio-N-methylindole (7) from 2,3-diiodo-N-methylindole ( 6) and subsequent reaction with various electrophiles (NH 4 Cl, DMF, ClCO 2 Me, CO 2 , phthalic anhydride) affords the corresponding 2,3-disubstituted indoles in good to excellent yields (41-99%).