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Synthesis of 2,2-disubstituted 4,9-dihydroxy-1h-benz(f)indene-1,3(2h)diones. a model sequence for the synthesis of fredericamycin

✍ Scribed by Kathlyn A. Parker; Kathleen A. Koziski; Gloria Breault

Publisher: Elsevier Science
Year: 1985
Tongue: French
Weight: 131 KB
Volume: 26
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)98956-1

No coin nor oath required. For personal study only.

✦ Synopsis

Among the known antitumor compounds, a unique structural feature is the Spiro ring system of fredericamycin A (1j.l Recently, Rama Rao et al. prepared the model spiro(4,4) nonane Z2 from a 2-aryl 1,3-indanedione.3

The report of that conversion prompts our communication of an alternative approach to joining the two perpendicular moieties of fredericamycin; our strategy led to the construction of the frederieamycin model 3.

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