Introduction. -Muscone (l), a perfumistically important macrocyclic ketone, has attracted considerable synthetic interest over the past sixty years'). An attractive approach is the three-C-atom ring-expansion concept developed in Firmenich research laboratories and which involves cleavage of a cycl
Synthesis of 2,15-Hexadecanedione as a Precursor of Muscone
โ Scribed by Guo Yuan; Gu Huan; Shi Zhen
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 38 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0256-7660
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## ABSTRACT An expedient synthesis of (__E__)โ3โmethylcyclopentadecโ2โenโ1โone, an important precursor for (__R__)โ(โ)โmuscone, was developed. The key steps were vapourโphase intramolecular aldol condensation catalysed by zinc oxide at 360โยฐC followed by double bond isomerization by the additionโel