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Synthesis of 2′-α-C-allenyl-2′-deoxyuridine: An analogue of 2′-azido-2′-deoxyuridine, known inhibitor of ribonucleotide diphosphate reductase (RDPR)

✍ Scribed by Mélanie Ethève - Quelquejeu; Jean-Marc Valéry


Book ID
104261700
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
164 KB
Volume
40
Category
Article
ISSN
0040-4039

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Synthesis of 2′-deoxyuridine 5′-(α,β-imi
✍ Tina Persson; Gunilla Larsson; Per Olof Nyman 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 400 KB

The dUDP analogue, 2'-deoxyuridine 5'-(alpha,beta-imido)diphosphate (dUPNP) was synthesized. The corresponding triphosphate analogue (dUPNPP) was prepared by enzymic phosphorylation of dUPNP using the enzyme pyruvate kinase and phosphoenolpyruvate as the phosphate donor. This method was successful i