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Synthesis of 2-substituted tetrahydrofurans

✍ Scribed by N. P. Volynskii; L. I. Perepelitchenko


Publisher
Springer US
Year
1988
Tongue
English
Weight
316 KB
Volume
24
Category
Article
ISSN
0009-3122

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Synthesis of substituted tetrahydrofuran
✍ Ichio Noda; Kiyoshi Horita; Yuji Oikawa; Osamu Yonemitsu πŸ“‚ Article πŸ“… 1986 πŸ› Elsevier Science 🌐 French βš– 232 KB

A new acid-catalyzed synthesis of thermodynamically stable 2,5\_substituted tetrahydrofurans and 2,6\_substituted tetrahydropyrans was developed in order to apply to the synthesis of complex polyether antibiotics.

Metallated 2-Alkenyl Sulfoximines in Asy
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## Abstract Starting from the enantiopure 2‐alkenyl sulfoximines 4/5 and __epi__‐4/5, a one‐pot procedure has been developed for the synthesis of tri‐ and tetrasubstituted tetrahydrofuran derivatives with excellent control of all relevant aspects of their structural description. The cyclization of