Synthesis of 2-Substituted Pyrano[2,3-d]Pyrimidin- 4(3H)-One Derivatives Using Iminophosphorane
β Scribed by Ren, Qing-Yun; He, Hong-Wu
- Book ID
- 127331877
- Publisher
- Taylor and Francis Group
- Year
- 2008
- Tongue
- English
- Weight
- 100 KB
- Volume
- 183
- Category
- Article
- ISSN
- 1042-6507
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## Abstract The carbodiimides **4**, obtained from reactions of iminophosphorane **3** with aromatic isocyanates, were reacted with secondary amines to give 2βdialkylaminoβ5βethylβ6βmethylβthieno[2,3β__d__]pyrimidinβ4(3__H__)βones **6** in the presence of catalytic amount of EtONa. Reactions of **4
A series of new, 2-substituted 3-aryl-8,9,10,11-tetrahydro-5-methyl[1]benzothieno [3',2' : 5,6]pyrido [4,3-d]pyrimidin-4(3H)-ones, compounds 5a -q, were designed and synthesized via the aza-Wittig reaction as the key step. The iminophosphorane 1 reacted with phenyl isocyanate (or 4-chlorophenyl isoc