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Synthesis of 2-Substituted Pyrano[2,3-d]Pyrimidin- 4(3H)-One Derivatives Using Iminophosphorane

✍ Scribed by Ren, Qing-Yun; He, Hong-Wu


Book ID
127331877
Publisher
Taylor and Francis Group
Year
2008
Tongue
English
Weight
100 KB
Volume
183
Category
Article
ISSN
1042-6507

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## Abstract The carbodiimides **4**, obtained from reactions of iminophosphorane **3** with aromatic isocyanates, were reacted with secondary amines to give 2‐dialkylamino‐5‐ethyl‐6‐methyl‐thieno[2,3‐__d__]pyrimidin‐4(3__H__)‐ones **6** in the presence of catalytic amount of EtONa. Reactions of **4

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A series of new, 2-substituted 3-aryl-8,9,10,11-tetrahydro-5-methyl[1]benzothieno [3',2' : 5,6]pyrido [4,3-d]pyrimidin-4(3H)-ones, compounds 5a -q, were designed and synthesized via the aza-Wittig reaction as the key step. The iminophosphorane 1 reacted with phenyl isocyanate (or 4-chlorophenyl isoc