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Synthesis of 2-Substituted-5-halo-2,3-dihydro-4( H )-pyrimidin-4-ones and Their Derivatization Utilizing the Sonogashira Coupling Reaction in the Enantioselective Synthesis of α-Substituted β-Amino Acids

✍ Scribed by Díaz-Sánchez, Blanca R.; Iglesias-Arteaga, Martín A.; Melgar-Fernández, Roberto; Juaristi, Eusebio


Book ID
121456540
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
97 KB
Volume
72
Category
Article
ISSN
0022-3263

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## Abstract A simple protocol for the Pd(OAc)~2~‐catalyzed cross‐coupling reaction of 1‐benzoyl‐(2__S__)‐isopropyl‐5‐iodo‐2,3‐dihydro‐4(__H__)‐pyrimidin‐4‐ones with potassium aryltrifluoroborates was developed. The reaction is performed at 110 °C with a ligand‐free catalyst. In all cases, complete