Synthesis of 2-(phenyltrifluoroacetylamino)-3-(trimethylsiloxy) alkanoic acid and N-phenyl-N-trifluoroacetyldehydroamino acid esters

✍ Scribed by Andrea Jacobsen-Bauer; Gerhard Simchen

• Book ID: 104203665
• Publisher: Elsevier Science
• Year: 1988
• Tongue: French
• Weight: 308 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(01)86042-7

✦ Synopsis

Reaction of aranmtic aldehyde8 1 with the ketone acetal 2 In presence of zinc bromide affords methyl 2-(phenyltrffluoroacetylamino)-+triwthylsiloxyalkanoatea 2. Elimination of trimethylailanole fran 2 by wanm of trifluoroacetic acid anhydride yields (E,Z) methyl 2-(phenyltrifluoroacetyl-amino)-2-alkenoates 5.