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Synthesis of 2-phenylimidazo[2,1-b]benzothiazole derivatives as modulators of multidrug resistance for tumor cells

✍ Scribed by Shigeyuki Tasaka; Hirokazu Tanabe; Yoshiyuki Sasaki; Toshiki Machida; Mayumi Iino; Akira Kiue; Seiji Naito; Michihiko Kuwano

Publisher: Journal of Heterocyclic Chemistry
Year: 1997
Tongue: English
Weight: 360 KB
Volume: 34
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570340620

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✦ Synopsis

We have investigated 3-substituted-2-phenylimidazo[2,1-b]benzothiazole derivatives and herein we have discussed their pharmaceutical activities. We found that some 2-phenyl-5,6,7,8-tetrahydroimidazo[2,1-b]benzothiazoles could overcome multidrug resistance for tumor cells. Among them, 2 -phenyl-3-( (N)-methyl3-piperidyl)carbonylaminoiminomethyl-5,6,7,8-tetrahydroimidazo[2,1-b]benzothiazole [N276-12] demonstrated the most potent activity for overcoming multidrug resistance.

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