Synthesis of 2-phenyl-1,2-benziso[77Se]selenazol-3(2H)-one: “Ebselen”

✍ Scribed by Jossian Oppenheimer; Louis A. Silks III

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: French
• Weight: 242 KB
• Volume: 38
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/(sici)1099-1344(199603)38:3<281::aid-jlcr833>3.0.co;2-1

✦ Synopsis

Synthesis of 2-Phenyl-1,2-benzi~o[~~Se]selenazol-3(2H)-one has been accomplished in one step from 94% 77Se and commercially available starting materials in 76% yield based on the enriched elemental selenium.