Synthesis of 2-(p-nitrophenoxy)ethylamine and its N-alkyl, N-aryl, and 1,1-dimethyl derivatives
β Scribed by Knipe, Anthony C.; Sridhar, Narayan; Lound-Keast, Joseph
- Book ID
- 125809617
- Publisher
- Royal Society of Chemistry
- Year
- 1977
- Weight
- 376 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1472-7781
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## Abstract magnified image Cyclocondensation of 2βacylphenylacetonitriles **1** with amines affords 1βsubstituted 3βaminoisoquinolines **2** in good yields.
2-Aryl-N,N-dimethyl-1,3-imidazolidines and 2-aryl-1,3-dioxolanes were subjected to 70 eV spectral analysis. Fragmentation pathways for both series of compounds are suggested. Aryl us. benzylic hydrogen fragmentations were subjected to Hammett cr+p plots. Incipient charge on the benzyl carbonium ion