𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of 2-Oxopyridine-Fused 1,3-Diazaheterocyclic Compounds via a Three-Component Reaction

✍ Scribed by Abdolali Alizadeh; Azadeh Mikaeili; Tahereh Firuzyar; Mahdi Ahmadi

Publisher
John Wiley and Sons
Year
2011
Tongue
German
Weight
148 KB
Volume
94
Category
Article
ISSN
0018-019X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

An efficient and simple route for the preparation of 2‐oxopyridine‐fused 1,3‐diazaheterocyclic compounds via a three component reaction is described. It involves the reaction between alkylenediamines 1, 1,1‐bis(methylsulfanyl)‐2‐nitroethene, and alkyl prop‐2‐ynoates 2 in refluxing THF (Table). The structures were corroborated by spectroscopic (IR, ^1^H‐ and ^13^C‐NMR, and EI‐MS) and elemental analyses. A plausible mechanism for this type of cyclization is proposed (Scheme).

📜 SIMILAR VOLUMES

A Novel and Efficient Synthesis of Pyrid
A Novel and Efficient Synthesis of Pyrido[1,2-a]-Fused 1,3-Diazaheterocyclic Compounds via a One-Pot Three-Component Reaction
✍ Abdolali Alizadeh; Atieh Rezvanian 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 German ⚖ 160 KB 👁 1 views

## Abstract An efficient one‐pot synthesis of pyrido[1,2‐__a__]‐fused 1,3‐diazaheterocyclic compounds by three‐component reaction of diamine, nitroketene dithioacetal (=1,1‐bis(methylsulfanyl)‐2‐nitroethene), and electron‐poor itaconic anhydride (=2‐methylidenesuccinic anhydride=2‐methylidenebutane